Mitochonic acid 5 ( MA-5 )

产品货号. M22041 CAS No. 1354707-41-7

线粒体酸 5 是植物激素吲哚-3-乙酸的衍生物。线粒体酸 5 结合线粒体并改善肾小管和心肌细胞损伤。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥786	有现货
10MG	￥1531	有现货
25MG	￥3062	有现货
50MG	￥4601	有现货
100MG	￥6602	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Mitochonic acid 5
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

线粒体酸 5 是植物激素吲哚-3-乙酸的衍生物。线粒体酸 5 结合线粒体并改善肾小管和心肌细胞损伤。
产品描述

Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis.
体外实验

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体内实验

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同义词

MA-5
通路

Others
靶点

Other Targets
受体

Mitochondrial Metabolism
研究领域

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适应症

——

化学信息

CAS Number

1354707-41-7
分子量

329.3
分子式

C18H13F2NO3
纯度

>98% (HPLC)
溶解度

DMSO:95 mg/mL (288.49 mM)
SMILES

OC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C1=CNC2=CC=CC=C12
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.2. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册