Mitochonic acid 5

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Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.

Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis.

MA-5

Others

Other Targets

Mitochondrial Metabolism

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1354707-41-7

329.3

C18H13F2NO3

>98% (HPLC)

DMSO:95 mg/mL (288.49 mM)

OC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C1=CNC2=CC=CC=C12

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(-20℃)

With Ice Pack

≥ 2 years