Mitochonic acid 5
CAS No. 1354707-41-7
Mitochonic acid 5 ( MA-5 )
产品货号. M22041 CAS No. 1354707-41-7
Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥786 | 有现货 |
|
10MG | ¥1531 | 有现货 |
|
25MG | ¥3062 | 有现货 |
|
50MG | ¥4601 | 有现货 |
|
100MG | ¥6602 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Mitochonic acid 5
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.
-
产品描述Mitochonic acid 5 is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases.Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis.
-
同义词MA-5
-
通路Others
-
靶点Other Targets
-
受体Mitochondrial Metabolism
-
研究领域——
-
适应症——
化学信息
-
CAS Number1354707-41-7
-
分子量329.3
-
分子式C18H13F2NO3
-
纯度>98% (HPLC)
-
溶解度DMSO:95 mg/mL (288.49 mM)
-
SMILESOC(=O)C(CC(=O)C1=C(F)C=C(F)C=C1)C1=CNC2=CC=CC=C12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.2. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32.
产品手册
关联产品
-
Delphinidin-3-O-gala...
Delphinidin-3-O-galactoside chloride has anti-obesity and hypolipidemic effects. Delphinidin-3-O-galactoside (D3G) is a water-soluble anthocyanin with antioxidant activity.
-
Regaloside D
Regaloside D is a natural product isolated from Lilium Longiflorum.
-
Jervine
The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened.